Current Issue : October - December Volume : 2018 Issue Number : 4 Articles : 6 Articles
Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive\nproperty to abnormal physiological environment as well as the original property to normal physiological environment. However,\nthe drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pHsensitive\ncomposite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated\nÃ?²-cyclodextrin (Ac-Ã?²-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic\nresponse. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure\nAc-Ã?²-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-Ã?²-CD. Furthermore, the structural\ninformation was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite\nnanoparticle possessed structural characteristic of both Ac-Ã?²-CD and Fe3O4. Composite nanoparticle exhibited sphere and\ntwo-phase morphology with the diameter of about 200ââ?¬â??250nm depending on their detection method and zeta potential of âË?â??12\nto âË?â??14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in\nneutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug\nloading and release behavior were investigated through preliminary in vitro evaluation....
Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely\nused as Micro- and Nano-carriers of therapeutic agents for drug delivery applications.\nHowever, encapsulation process of therapeutic agents into PLGA\nNanoparticles (NPs) necessitates a defined step to understand the effects and\ninteractions of parameters involved in production process. In pharmaceutics\nformulations, compared to one factor at a time (OFAT) approach, statistical\ndesign of experiments (DOE) supersedes OFAT approach due to limited\nnumber of experiments required to investigate effects and interactions of a\nprocess parameters. The major objectives of the present study were to: 1) prepare\nand understand the effect of selected formulation parameters on particles\nsize and drug recovery of PLGA NPs encapsulating Ciprofloxacin Hydrochloride\n(Cip-HCl) using a fractional factorial design (FFD) as a DOE approach;\n2) understand the in -vitro release of Cip-HCl from PLGA NPs. Cip-HCl\nloaded PLGA were prepared by W1/O/W2 double emulsion solvent evaporation\n(DESE) method using poly-vinyl alcohol as a stabilizer. The Sizes of NPs\nwere within 202 nm to 530 nm and percentage Cip-HCl recovered from dried\nNPs were within 1.7% w/w to 15.7% w/w. Increasing concentrations of PLGA\nand Cip-HCl was observed to increase NPs size. Increasing PVA concentration\nwas observed to either reduce or increase NPs size. Increasing PLGA\nconcentration was observed to increase the amount of Cip-HCl recovered.\nWithin 1 - 24 hours, optimized formulations shows a controlled release of\nCip-HCl from PLGA NPs....
The present work employed preparation of metaxalone nanocrystals (MNC) by emulsion solvent diffusion method using β-cyclodextrin (CD) as stabilizer. Nanocrystals were characterized for morphology by scanning electron microscopy, crystallinity by powder x-ray diffraction and particle size by zeta sizer. Solubility study of metaxalone (MTX) and MNC was performed in distilled water, 7.4 phosphate buffer and 0.1N Hydrochloric acid. Preparation of MNC in size range of 450-650 nm was done successfully. An inverse relationship between size and zeta was observed. Further 2 fold enhancement in aqueous solubility and elevated drug release profile for formulated nanocrystals was observed. In conclusion MNC prepared demonstrated to be a rising approach for enhancing the solubility and bioavailability of MTX....
Nanosuspensions have emerged as a promising strategy for the efficient delivery of drugs because of their versatile features and unique advantages. Nanosuspensions are colloidal dispersions and biphasic system consisting of drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1 μm in size. Reduction of drug particles to nanometer range leads to an enhanced dissolution rate due to increased surface area and saturation solubility. The formulation of nanosuspension includes stabilizer, polymer, organic solvent, co-surfactant, drugs and other additives. Nanosuspension can be prepared by various methods like top-down methods, bottom-up methods and methods employing combinatorial approaches etc. The electrostatic repulsion and steric stabilization are the two theories behind the formulation of nanosuspension. This review article describes the methods and characterization of the Nanosuspension....
In the present study, controlled release sertaconazole nitrate (SZN) microsponge gel for topical delivery was formulated and evaluated. Microsponges were prepared successfully using six different proportions of ethyl cellulose as a polymer, using PVA as surfactant by the quasi-emulsion solvent diffusion method. The influence of the drug to polymer ratio, surfactant concentration, inner phase volume and stirring speed on the drug entrapment efficiency and physical characteristics of the microsponges were investigated. Compatibility of the drug with adjuncts was investigated by FT-IR and DSC. SEM analysis was used to study surface morphology which showed spherical and spongy nature of microsponges. The particle size of the optimized formulations was in between 300-450 µm and the drug entrapment efficiency was in the range of 45.23 % to 91.49 %. These microsponge gel formulations were prepared using carbopol 934 and studied for pH, viscosity and in-vitro drug release. The batch G3 was considered to be optimal as it shown 71.23 % drug diffused within 24 hrs....
We have synthesized hollow mesoporous silica (HMS) at a zeolitic imidazolate framework (ZIF) capsule that can be used as a drug\ndelivery system for gentamicin (GM). The GM is first loaded into HMS. Then, the outer surface of the GM/HMS is coated with\nuniformed ZIF nanoparticles (denoted as GM/HMS@ZIF). The GM/HMS@ZIF has been successfully prepared and acts as a\ncapsule for GM. The GM/HMS@ZIF shows a good biocompatibility and a good cellular uptake in House Ear Institute-Organ of\nCorti 1 (HEI-OC1) cells. The GM is released slowly within 10 h under acidic conditions, which is used to simulate the pH of the\nendosome and lysosome compartments. The in vivo assay shows that the signal from fluorescein isothiocyanate (FITC) can be\nobserved after 15 days, when the mice were injected with FITC/HMS@ZIF. This opens new opportunities to construct a delivery\nsystem for GM via one controlled low dose and sustained release for the therapy of M�©ni�¨reâ��s disease....
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